Process Chemistry
Process development work for the Active Pharmaceutical Ingredients (APIs) is carried out by the Chemical Process Research Laboratory, which focuses on developing commercially viable eco-friendly processes for intermediates and APIs for the regulated global markets.
Capabilities
Chemistry :
- Heterocyclic chemistry
- Catalytic hydrogenations
- Organic transformations of wide and varied types
- Classical and dynamic resolutions
- Asymmetric synthesis using chiral pool, enantio /diastereo-selective reactions
- Polymer Chemistry
- Green chemistry
- Biocatalysis
Process :
- Development of novel/non-infringing processes for APIs
- Development of environment friendly processes
- Development of Chiral APIs
- Ability to comply with ICH guidelines
- Synthesis, isolation and characterization of impurities
- Expertise in handling pyrophoric reagents
- Expertise in very low temperature (-90°C) reactions
Analytical :
- Development of in-process analytical methods
- Isolation and identification of impurities
- Enantiomer separation using chiral HPLC/GC columns
Polymorphism :
- Synthesis of novel Polymorphs
- Synthesis of amorphous forms using lyophilization, spray drying or solvent evaporation techniques
- Development of novel processes for known Polymorphs
- Quantification studies of Polymorphs using IR/DSC/XRPD
- Determination of Polymorph stability